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KMID : 0811720010050060451
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Korean Journal of Physiology & Pharmacology
2001 Volume.5 No. 6 p.451 ~ p.456
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Effect of Kainic Acid on the Phosphorylation of Mitogen Activated Protein Kinases in Rat Hippocampus
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Je Seong Won
Jin Koo Lee/Seong Soo Choi/Dong Keun Song/Sung Oh Huh/Yung Hi Kim/Hong Won Suh
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Abstract
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In rat hippocampus, kainic acid (KA; 10 mg/kg; i.p.) increased the phosphorylated forms of ERK1/2 (p-ERK1/2) and Jun kinase1 (p-JNK1), but not p-JNK2 and p38 (p-p38). The preadministration with cycloheximide (CHX; 5 mg/kg; i.p.) inhibited KA-induced increase of p-JNK1, but not p-ERK1/2. Surprisingly, the phosphorylated upstream MAP kinase kinases (p-MKKs) were not correlated with their downstream MAP kinases. The basal p-MKK1/2 levels were completely abolished by KA, which were reversed by CHX. In addition, p-MKK4 and p-MKK3/6 levels were enhanced by CHX alone, but were attenuated by KA. Thus, our results showed that KA increased the p-ERK and p-JNK levels in rat hippocampus, which were not parallel with their classical upstreamal kinases.
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KEYWORD
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Kainic acid, Cycloheximide, ERK, JNK, p38, Phosphorylation, MKK, Hippocampus,
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